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Ongoing Research Support:
NSF Function of Tissue-specific eIF4E Isoforms in Caenorhabditis elegans This study addresses how initiation factor isoforms govern translational control of gene expression in embryogenesis and gametogenesis. Role: Principle Investigator 
Leo W. Jenkins Cancer Research Grant Farwell and Keiper (coPI's) 1/06 to 12/06 Leo W. Jenkins Cancer Center, Pilot/Collaborative Research Grants Targeted depletion of isoforms in breast cancer cell lines reduces proliferation and increases apoptosis. This study looks at blocking expression of specific translation initiation factor eIF4G isoforms to see if proliferation is inhibited and apoptosis promoted. Role: Co-Principle Investigator Instrumentation Grant Support: 
2004-IDG 1002 Keiper and McCubrey (co-PI's) 2/1/05 to 1/31/06 North Carolina Biotechnology Center, Institutional Development Grant Phosphor-Imaging and Fluorescence-Imaging Core Facility (Brody School of Medicine at ECU) Funds were awarded for the purchase of a multipurpose gel and array scanning facility to visualize and quantify radioactive, fluorescent and chemiluminescent signals. Role: Principle Investigator Completed Research Support: ECU ACS-IRG 5-89812 Keiper (PI) 7/1/03 to 6/30/04 American Cancer Society Reducing Cell Proliferation by Translation Factor eIF4G Depletion: C. elegans as a model for transformed cells This study probes the role of translation factor eIF4G in the rapid growth characteristic of embryonic and cancer cells. Role: Principle Investigator |
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East Carolina University
Brett D. Keiper, Ph.D. Dept of Biochemistry & Molecular Biology Brody School of Medicine Greenville, NC 27858 keiperb@ecu.edu
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bd keiper 12/06 |